Not just artists - we all go through life’s ups and downs, good periods and bad. Right now is the least tolerant time since I’ve been alive. Everyone’s supposed to be on it 24/7.

Viewed in the context of the episode, Sylvester is talking, specifically, about the “professionalization” and “commercialization” of art, and basically the hype machine of the art world.
Source: Artists must be allowed to make bad work | Austin Kleon