Tag: COVID

5 main concerns of top scientists about the relaxing of UK Covid restrictions

This warning to the UK government with the ‘five main concerns’ of top scientists is quite concerning.

First, unmitigated transmission will disproportionately affect unvaccinated children and young people who have already suffered greatly. Official UK Government data show that as of July 4, 2021, 51% of the total UK population have been fully vaccinated and 68% have been partially vaccinated. Even assuming that approximately 20% of unvaccinated people are protected by previous SARS-CoV-2 infection, this still leaves more than 17 million people with no protection against COVID-19. Given this, and the high transmissibility of the SARS-CoV-2 Delta variant, exponential growth will probably continue until millions more people are infected, leaving hundreds of thousands of people with long-term illness and disability. This strategy risks creating a generation left with chronic health problems and disability, the personal and economic impacts of which might be felt for decades to come.

Second, high rates of transmission in schools and in children will lead to significant educational disruption, a problem not addressed by abandoning isolation of exposed children (which is done on the basis of imperfect daily rapid tests). The root cause of educational disruption is transmission, not isolation. Strict mitigations in schools alongside measures to keep community transmission low and eventual vaccination of children will ensure children can remain in schools safely This is all the more important for clinically and socially vulnerable children. Allowing transmission to continue over the summer will create a reservoir of infection, which will probably accelerate spread when schools and universities re-open in autumn.

Third, preliminary modelling data9 suggest the government’s strategy provides fertile ground for the emergence of vaccine-resistant variants. This would place all at risk, including those already vaccinated, within the UK and globally. While vaccines can be updated, this requires time and resources, leaving many exposed in the interim. Spread of potentially more transmissible escape variants would disproportionately affect the most disadvantaged in our country and other countries with poor access to vaccines.

Fourth, this strategy will have a significant impact on health services and exhausted health-care staff who have not yet recovered from previous infection waves. The link between cases and hospital admissions has not been broken, and rising case numbers will inevitably lead to increased hospital admissions, applying further pressure at a time when millions of people are waiting for medical procedures and routine care.

Fifth, as deprived communities are more exposed to and more at risk from COVID-19, these policies will continue to disproportionately affect the most vulnerable and marginalised, deepening inequalities.

Source: Mass infection is not an option: we must do more to protect our young | The Lancet

Fractional dosing of COVID vaccines may help more people get immunity faster

The advice to date has, quite rightly, to get any COVID vaccine that’s available to you. For me, that’s meant a double dose of AstraZeneca, and I’m happy about that.

But as the pandemic progresses, we need to be aware that some vaccines are more effective than others. This working paper, building on one published in Nature earlier this year, looks at how ‘fractional dosing’ of the Moderna and Pfizer vaccines could reach more people more quickly.

Needless to say, we shouldn’t be in the position where people in less developed countries are getting access to vaccines much more slowly than the rest of the world. But, pragmatically speaking, this may help.

We supplement the key figure from Khoury et al.’s paper to show that fractional doses of the Moderna and Pfizer vaccines have neutralizing antibody levels (as measured in the early phase I and phase II trials) that look to be on par with those of many approved vaccines. Indeed, a one-half or one-quarter dose of the Moderna or Pfizer vaccine is predicted to be more effective than the standard dose of some of the other vaccines like the AstraZeneca, J&J or Sinopharm vaccines, assuming the same relationship as in Khoury et al. holds. The point is not that these other vaccines aren’t good–they are great! The point is that by using fractional dosing we could rapidly and safely expand the number of effective doses of the Moderna and Pfizer vaccines.

[…]

One more point worth mentioning. Dose stretching policies everywhere are especially beneficial for less-developed countries, many of which are at the back of the vaccine queue. If dose-stretching cuts the time to be vaccinated in half, for example, then that may mean cutting the time to be vaccinated from two months to one month in a developed country but cutting it from two years to one year in a country that is currently at the back of the queue.

Source: A Half Dose of Moderna is More Effective Than a Full Dose of AstraZeneca | Marginal REVOLUTION